ILSI Research Foundation
Workshop: Evaluating the Human Relevance of Modes of Action in Animals
Cohen SM, Meek ME, Klaunig JE, Patton DE, and Fenner-Crisp PA (2003). The human relevance of information on carcinogenic modes of action: Overview. Critical Reviews in Toxicology, 33:581-589.
Meek ME, Bucher JR, Cohen SM, Dellarco V, Hill RN, Lehman-McKeeman LD, Longfellow DG, Pastoor T, Seed J, and Patton DE (2003). A framework for human relevance analysis of information on carcinogenic modes of action. Critical Reviews in Toxicology, 33:591-653. [This entire issue of Critical Reviews in Toxicology (Vol. 33, Issue 6, pp. 581-780) comprises the report of the ILSI Risk Science Institute Working Group on the human relevance of cancer modes of action in animals.]
Seed J, Carney EW, Corley RA, Crofton KM, DeSesso JM, Foster PMD, Kavlock R, Kimmel G, Klaunig J, Meek ME, Preston RJ, Slikker (Jr) W, Tabacova S, Williams GM, Wiltse J, Zoeller RT, Fenner-Crisp PA, and Patton DE (2005). Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data. Critical Reviews in Toxicology, 35:663-672. [This entire issue of Critical Reviews in Toxicology (Vol. 35, Issues 8-9, pp. 663-781) comprises the report of an ILSI Risk Science Institute Working Group extending the 2003 human relevance framework to genotoxic carcinogens and non-cancer endpoints.]
Sonich-Mullin C, Fielder R, Wiltse J, Baetcke K, Dempsey J, Fenner-Crisp P, Grant D, Hartley M, Knaap A, Kroese D, Mangelsdorf I, Meek ME, Rice JM, and Younes M (2001). IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis. Regulatory Toxicology and Pharmacology, 34:146-152.
U.S. EPA Guidelines for Carcinogen Risk Assessment (2005). Available at: http://www.epa.gov/cancerguidelines.
WHO/ILO/UNEP International Programme on Chemical Safety Risk Assessment Harmonization Project work on mode of action in cancer risk assessment: http://www.who.int/ipcs/methods/harmonization/areas/cancer/en/index.html.
Boobis AR, Cohen SM, Dellarco V, McGregor D, Meek ME, Vickers C, Willcocks D, and Farland W (2006). IPCS framework for analyzing the relevance of a cancer mode of action for humans. Critical Reviews in Toxicology 36:781-792 [This entire issue of Critical Reviews in Toxicology addresses the IPCS framework.]