Scientific Peer Review to Inform Regulatory Decisions: Leadership Responsibilities and Cautions, Dorothy Patton, Ph.D., J.D, Consultant, and Stephen Olin, Ph.D., Acting Executive Director, ILSI Risk Science Institute, January 2005. The immediate audience for this report on “leadership responsibilities and cautions” relating to peer review is the leadership community within the federal agencies. This community includes decision-makers and senior executives who are responsible to Congress, the courts and the public for scientifically credible regulatory decisions. Nine brief explanatory essays, presented as tips to these leaders on shaping peer review programs and navigating the upper levels of the peer review process, form the centerpiece of the report. Topics range from preliminary steps involved in planning a review to end-stage use of peer review comments to complete a report. The report takes a “heads up” rather than a “how to” approach. A paper adapted from this ILSI RSI report has been accepted for publication in Risk Analysis: An International Journal.
Principles & Practices for Direct Dosing of Pre-Weaning Mammals in Toxicity Testing and Research, edited by Tracy Zoetis and Isabel Walls, is a state-of-the-art text that offers guidance on how to undertake a direct dosing laboratory study on pre-weaning mammals. Species selection, study design issues, dosing methodologies, kinetics, and data interpretation are all covered in this important publication. The book retails for $60.00 (ISBN 1-57881-169-4, order number 811694). For order information, click here. To read the table of contents and introduction click here.
A critical aspect of RSI’s work is the dissemination of the products of RSI activities. Below we list some of the more recent publications prepared by RSI.
Daston G, Faustman E, Ginsberg G, Fenner-Crisp P, Olin S, et al. A framework for assessing risks to children from exposure to environmental agents. Environ Health Perspect. 2004;112:238-256.
Ginsberg G, Slikker W Jr, Bruckner J, Sonawane B. Incorporating children's toxicokinetics into a risk framework. Environ Health Perspect. 2004;112:272-283.
Julien E; ILSI RSI Working Group on Probabilistic Worker Exposure Assessment. Probabilistic methods to assess worker exposure to agricultural pesticides. Poster presented at: Society of Toxicology Annual Meeting; March 21-25, 2004; Baltimore, MD.
Julien E, Willhite CC, Richard AM, DeSesso JM; ILSI RSI Working Group. Challenges in constructing statistically based structure-activity relationship models for developmental toxicity. Birth Defects Res A Clin Mol Teratol. 2004;70:902-911.
Landrigan PJ, Kimmel CA, Correa A, Eskenazi B. Children's health and the environment: public health issues and challenges for risk assessment. Environ Health Perspect. 2004;112:257-265.
Morford LL, Henck JW, Breslin WJ, Desesso JM. Hazard identification and predictability of children's health risk from animal data. Environ Health Perspect. 2004;112:266-271.
Olin SS, and the ILSI RSI Fiber Toxicity Assay Working Group. Toxicity testing of fibrous particles: the appropriate use of short-term assays. Poster presented at: Society of Toxicology Annual Meeting; March 21-25, 2004; Baltimore, MD.
Walls I. Achieving continuous improvements in reductions in foodborne Listeriosis – a risk-based approach. Paper presented at: Annual Meeting of the American Association for the Advancement of Science; February 12-16, 2004; Seattle, WA.
Walls I. Use of screening tools for potentially toxic chemicals in context-based decision-making. Poster presented at: Society of Toxicology Annual Meeting; March 21-25, 2004; Baltimore, MD.
Walls I. Using risk-based approaches for managing food safety. Paper presented at: 4th Asian Food and Nutrition Safety Conference; March 2-5, 2004; Nusa Dua, Bali, Indonesia.
Walls I, Zoetis T. Principles and practices for direct dosing of pre-weaning mammals in toxicity testing and research. Poster presented at: Society of Toxicology Annual Meeting; March 21-25, 2004; Baltimore, MD.
Additional select publications are listed below:
Achieving Continuous Improvement In Reductions In Foodborne Listeriosis – A Risk Based Approach (2004)
Workshop to Develop a Framework for Assessing Risks to Children from Exposures to Environmental Agents (2003)
Principles & Practices for Direct Dosing of Pre-Weaning Mammals in Toxicity Testing and Research (2003)
Framework for Risk Assessment Training Workshop Summary (2002)
Towards Harmonised Guidance on Applying Probabalistic Methods to Assess Operator Exposure to Plant Protection Products (2002)
Revised Framework for Microbial Risk Assessment (2000)
Early Warning Monitoring to Detect Hazardous Events in Water Supplies (1999)
Exposure to Contaminants in Drinking Water: Estimating Uptake Through the Skin and by Inhalation (1999)
A Framework for Estimating Pesticide Concentrations in Drinking Water for Aggregate Exposure Assessments (1999)
A Framework for Cumulative Risk Assessment (1999)
Aggregate Exposure Assessment (1998)