The human physiological parameters for early life stages database has been completed. Access to the database is free and available from this webpage. The database is a reference source of appropriate parameter values for physiologically-based pharmacokinetic (PBPK) or biologically-based dose-response (BBDR) models and subsequent use in risk assessment.
Click here to download a Microsoft Access version of the database.
Click here to download a PDF Annotated List of Fields Contained in the database.
The goal of this project was to generate a readily accessible, authoritative and comprehensive database of key physiological parameters at early life stages in humans. As the use of PBPK models in risk assessments increases, there has been a growing need for data on physiological parameter values (e.g., respiratory ventilation rates and volumes, body weight/surface area ratios, organ volumes and weights). In particular, there is a need for values relevant to early developmental life stages. This database brings together data on early life stage parameters that are scattered in many different publications in the literatures of diverse disciplines and specialties.
The ILSI RF/RSI project on physiological parameters was designed to build on related efforts by other investigators - e.g., efforts to compile PBPK modeling parameters for mice and rats (Haber et al. 2003; Gentry et al. 2005) for which a database is available on the U.S. EPA’s website. Also, the ILSI RF/RSI project aimed to expand and improve upon earlier efforts to compile parameter values (Arms and Travis 1988; Davies and Morris 1993; Brown et al. 1997) by including more recent data, as well as information on the variability associated with selected parameters.
This project has been funded through a cooperative agreement with U.S. Environmental Protection Agency, Office of Research and Development, and Health Canada. The database was constructed at ENVIRON International Corporation. Internal quality assurance procedures were used to limit data entry errors; however, use of the information is at the risk of the database user. Users who encounter problems with the database or who have data that would augment the existing database are encouraged to contact Julie Fitzpatrick at jfitzpatrick@ilsi.org or 202-659-3306.